Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels
نویسندگان
چکیده
منابع مشابه
Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels.
Digitoxin and other cardiac glycosides are important, centuries-old drugs for treating congestive heart failure. However, the mechanism of action of these compounds is still being elucidated. Calcium is known to potentiate the toxicity of these drugs, and we have hypothesized that digitoxin might mediate calcium entry into cells. We report here that digitoxin molecules mediate calcium entry int...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0712270105